Strategies for insulin therapy in type 2 diabetes
作者： Candis M. Morello , Steven V. Edelman
DOI: 10.1097/01.SMJ.0000149424.50849.00
关键词:
摘要: Chronic hyperglycemia in type 2 diabetes is responsible for an array of microvascular and macrovascular complications that can lead to significant morbidity mortality. Several well-conducted large clinical studies have shown normalizing blood glucose levels help prevent the onset slow progression from diabetes. As many as 25% patients treated with oral hypoglycemic agents require addition insulin therapy compensate beta-cell failure inability maintain glycemic control. Various strategies incorporating use early course disease been developed meet this goal, include basal-bolus regimens well bedtime injections. The pharmacokinetic properties new analogs (eg, lispro, aspart, glargine) offer advantages, such improved control nocturnal hypoglycemia basal glargine, postprandial control, lispro or aspart.
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