Efficacy of T-DM1 for leptomeningeal and brain metastases in a HER2 positive metastatic breast cancer patient: new directions for systemic therapy - a case report and literature review

摘要: Herein, we report a complete response after whole brain radiotherapy (WBRT) and concomitant T-DM1 in patient with HER2-positive metastatic breast cancer (MBC) extensive leptomeningeal involvement. A 46 years old Caucasian woman MBC no baseline CNS involvement, started August 2015 1st line therapy Pertuzumab-Trastuzumab-Docetaxel, partial response. However, April 2016 the eventually progressed emergence of metastases. Hence, she May 2nd WBRT, (CR) 3 courses therapy, resolution neurological symptoms relevant toxicities. The CR is lasting over 13 months out corticosteroid use. To best our knowledge, this first case reporting interesting antitumor activity WBRT both metastases, favorable safety profile prolonged extracranial disease control. Further prospective studies should confirm these findings.