Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat.
作者： Inga-Lill Junggren , Xiaohe Zhao , Xiangying Sun , Thomas Hedner
DOI: 10.1111/J.2042-7158.1996.TB03983.X
关键词:
摘要: Binding experiments show that ZD 7155 is a potent angiotensin II type 1 receptor antagonist. In this study novel substance was studied in normotensive and hypertensive rats. The relative potency duration of the antihypertensive effects were compared with those reference substance, losartan. inhibitory both compounds on II-induced pressor actions conscious Sprague-Dawley (SD) rat conscious, spontaneously (SHR). Arterial blood pressure heart rate (HR) obtained by direct intraarterial recording. Angiotensin infusion administered intravenously dose range 53.3 ng-12.8 μg kg -1 min to bolus 1.082 μmol [ - ' (0.51 mg ) losartan doses 2.165 6.495 (1.0 3.0 ). SD rats, behaved as competitive antagonists response curve shifted right. Experiments rats also showed approximately ten times suppressing (240 ng ; 10 infusion). addition, demonstrated could suppress for 24 h when given at 240 (in 10-min SHRs using (1.082 (6.495 intravenous boluses indicated compound exhibited significant effect. These results demonstrate II-type antagonist which response. Furthermore, may SHR induces pronounced persistent
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