The Pecten Oculi of the Chicken: A Model System for Vascular Differentiation and Barrier Maturation
作者： Hartwig Wolburg , Stefan Liebner , Andreas Reichenbach , Holger Gerhardt
DOI: 10.1016/S0074-7696(08)62417-1
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摘要: The pecten oculi is a convolute of blood vessels in the vitreous body avian eye. This structure well known for more than century, but its functions are still matter controversies. One these must be formation blood-retina barrier because there no diffusion blood-borne compounds available between and retina. Surprisingly, characteristics this organ have not been studied so far, although may constitute fascinating model vascular differentiation maturation: Pectinate endothelial cells grow by angiogenesis from ophthalmotemporal artery into primordium consecutively gain properties. pectinate pigmented arise during development retinal pigment epithelial subsequently lose These inverse transdifferentiation processes triggered peculiar microenvironment body. In addition, question discussed whether avascularity retina due to specific metabolic activity pecten.
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