Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis.

摘要: Purpose To characterize the topography of and cellular processes that underlie vascularization human retina. Methods The vasculature eyes obtained from fetuses ranging in age 14 to 38 weeks gestation (WG) was examined Nissl-stained, whole-mount preparations by anti-CD34 immunohistochemistry. Results first event retinal vascularization, apparent before 15 WG, migration large numbers spindle-shaped mesenchymal precursor cells optic disc. These proliferated differentiated produce cords endothelial cells. By some were already patent formed an immature vascular tree inner layers centered on are consistent with vessel formation vasculogenesis. Angiogenesis then increased density this plexus extended it peripherally temporally. Maturation characterized substantial remodeling, which involved withdrawal into neighboring segments. outer as a result extension capillary-sized buds existing vessels, process began around incipient fovea between 25 26 WG. Conclusions observations suggest primordial vessels central retina is mediated vasculogenesis, whereas angiogenesis responsible for increasing peripheral In contrast, radial peripapillary capillaries only. mechanisms appear similar those nervous system during development.