The Future of Blood Testing Is the Immunome
作者： Ramy A Arnaout , Eline T Luning Prak , Nicholas Schwab , Florian Rubelt , Rohit Arora
DOI: 10.3389/FIMMU.2021.626793
关键词:
摘要: It is increasingly clear that an extraordinarily diverse range of clinically important conditions-including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions, aging, and cancers-leave telltale signatures in the millions V(D)J-rearranged antibody T cell receptor [TR per Human Genome Organization (HUGO) nomenclature but more commonly known as TCR] genes collectively expressed by a person's B cells (antibodies) cells. We refer to these immunome. Because its diversity complexity, immunome provides singular opportunities for advancing personalized medicine serving substrate highly multiplexed, near-universal blood test. Here we discuss some opportunities, current state immunome-based diagnostics, highlight challenges involved. conclude with call clinicians, researchers, others join efforts Adaptive Immune Receptor Repertoire Community (AIRR-C) realize diagnostic potential
frontiersin.org
sci-hub.st 参考文章(59)
Christopher M Tipton, Christopher F Fucile, Jaime Darce, Asiya Chida, Travis Ichikawa, Ivan Gregoretti, Sandra Schieferl, Jennifer Hom, Scott Jenks, Ron J Feldman, Ramit Mehr, Chungwen Wei, F Eun-Hyung Lee, Wan Cheung Cheung, Alexander F Rosenberg, Iñaki Sanz, None, Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus Nature Immunology. ,vol. 16, pp. 755- 765 ,(2015) , 10.1038/NI.3175
Alexander Kröber, Till Seiler, Axel Benner, Lars Bullinger, Elsbeth Brückle, Peter Lichter, Hartmut Döhner, Stephan Stilgenbauer, VH mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia Blood. ,vol. 100, pp. 1410- 1416 ,(2002) , 10.1182/BLOOD.V100.4.1410.H81602001410_1410_1416
Uri Hershberg, Eline T. Luning Prak, The analysis of clonal expansions in normal and autoimmune B cell repertoires Philosophical Transactions of the Royal Society B. ,vol. 370, pp. 20140239- ,(2015) , 10.1098/RSTB.2014.0239
Peter J. Embi, Philip R.O. Payne, Evidence generating medicine: redefining the research-practice relationship to complete the evidence cycle. Medical Care. ,vol. 51, ,(2013) , 10.1097/MLR.0B013E31829B1D66
B S Briney, J R Willis, B A McKinney, J E Crowe, High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals Genes and Immunity. ,vol. 13, pp. 469- 473 ,(2012) , 10.1038/GENE.2012.20
Ranjini Valiathan, Khaled Deeb, Marc Diamante, Margarita Ashman, Naresh Sachdeva, Deshratn Asthana, Reference ranges of lymphocyte subsets in healthy adults and adolescents with special mention of T cell maturation subsets in adults of South Florida. Immunobiology. ,vol. 219, pp. 487- 496 ,(2014) , 10.1016/J.IMBIO.2014.02.010
B. M. Carreno, V. Magrini, M. Becker-Hapak, S. Kaabinejadian, J. Hundal, A. A. Petti, A. Ly, W.-R. Lie, W. H. Hildebrand, E. R. Mardis, G. P. Linette, A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells Science. ,vol. 348, pp. 803- 808 ,(2015) , 10.1126/SCIENCE.AAA3828
William H. Robinson, Sequencing the functional antibody repertoire—diagnostic and therapeutic discovery Nature Reviews Rheumatology. ,vol. 11, pp. 171- 182 ,(2015) , 10.1038/NRRHEUM.2014.220
Deborah K Dunn-Walters, Alexander A Ademokun, B cell repertoire and ageing. Current Opinion in Immunology. ,vol. 22, pp. 514- 520 ,(2010) , 10.1016/J.COI.2010.04.009
Wayne A Psek, Rebecca A Stametz, Lisa D Bailey-Davis, Daniel Davis, Jonathan Darer, William A Faucett, Debra L Henninger, Dorothy C Sellers, Gloria Gerrity, None, Operationalizing the Learning Health Care System in an Integrated Delivery System eGEMs (Generating Evidence & Methods to improve patient outcomes). ,vol. 3, pp. 1122- 1122 ,(2015) , 10.13063/2327-9214.1122