Computational Study of the Blood Flow in Three Types of 3D Hollow Fiber Membrane Bundles

摘要: The goal of this study is to develop a computational fluid dynamics (CFD) modeling approach better estimate the blood flow in bundles hollow fiber membrane based medical devices (i.e., oxygenators, artificial lungs, and hemodialyzers). Three representative types arrays, square, diagonal, random with porosity value 0.55, were studied. In addition, 3D array same was fields between individual fibers these arrays at selected Reynolds numbers (Re) simulated CFD modeling. Hemolysis not significant but platelet activation may be essential. For each type array, average wall shear stress linearly proportional Re. Re different also exhibits linear dependency on pressure difference across while Darcy's law prescribes power-law relationship, therefore, underestimating level. Re, diagonal approximately 3.1, 1.8, 2.0 times larger than that random, respectively. A coefficient C suggested correlate predicted data analytical solution, 1.16, 1.51, 2.05 for paper, It worth noting strongly dependent geometrical properties, whereas it weakly field. Additionally, bundle simulation results show three-dimensional effect negligible. Specifically, velocity distribution can vary significantly along axial direction.