The Activities of Vitamin D and Anti-Thyroperoxidase (Anti-TPO) Antibodies in Uncontrolled Type 2 Diabetes
作者： Ramana K.V.
DOI: 10.5376/IJMMS.2015.05.0001
关键词:
摘要: The fat soluble vitamin D, anti Thyroperoxidase (anti TPO) enzyme, an enzyme involved in thyroid hormone synthesis has a role uncontrolled type 2 diabetes mellitus (T2D). Vitamin D diverse functions human body and it carries out its function via receptors (VDR). This VDRs are present most types of immune cells. immuno modulator property is due to effects on T B lymphocytes. Thus, vitamins modifies cell mediated responses regulate inflammatory activity. In T2D, there insulin resistance (high titers antibodies), decreased activity increased TPO levels. study concludes probable relation between related activity, signaling molecules T2D which increases the progression this condition autoimmune disease.
medscipublisher.com参考文章(20)
Albert L Siu, Kirsten Bibbins-Domingo, David C Grossman, None, Screening for Thyroid Dysfunction Annals of Internal Medicine. ,vol. 163, pp. 564- 565 ,(2015) , 10.7326/L15-5141-2
Klaus Ganz, Diabetes Mellitus and Primary Hypothyroidism Archives of Internal Medicine. ,vol. 134, pp. 430- 432 ,(1974) , 10.1001/ARCHINTE.1974.00320210040005
Ifigenia Kostoglou-Athanassiou, Panagiotis Athanassiou, Anastasios Gkountouvas, Philippos Kaldrymides, Vitamin D and glycemic control in diabetes mellitus type 2 Therapeutic Advances in Endocrinology and Metabolism. ,vol. 4, pp. 122- 128 ,(2013) , 10.1177/2042018813501189
Anthony M Belenchia, Aneesh K Tosh, Laura S Hillman, Catherine A Peterson, Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial The American Journal of Clinical Nutrition. ,vol. 97, pp. 774- 781 ,(2013) , 10.3945/AJCN.112.050013
Astrid G.S. van Halteren, Odette M. Tysma, Evelyne van Etten, Chantal Mathieu, Bart O. Roep, 1α,25-Dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis Journal of Autoimmunity. ,vol. 23, pp. 233- 239 ,(2004) , 10.1016/J.JAUT.2004.06.004
J Feely, T E Isles, Screening for thyroid dysfunction in diabetics. BMJ. ,vol. 1, pp. 1678- 1678 ,(1979) , 10.1136/BMJ.1.6179.1678
J Mitri, M D Muraru, A G Pittas, Vitamin D and type 2 diabetes: a systematic review. European Journal of Clinical Nutrition. ,vol. 65, pp. 1005- 1015 ,(2011) , 10.1038/EJCN.2011.118
Fatma Dilek Dellal, Mutlu Niyazoglu, Esranur Ademoglu, Suheyla Gorar, Zehra Candan, Handan Bekdemir, Ziynet Alphan Uc, Mehmet Senes, Aysenur Ozderya, Yalcin Aral, Evaluation of Serum Trace Elements and Vitamin Levels in Hashimoto’s Thyroiditis: Single Centre Experience from Turkey Open Journal of Endocrine and Metabolic Diseases. ,vol. 03, pp. 236- 240 ,(2013) , 10.4236/OJEMD.2013.34031
David E. Goldstein, Allan Drash, Julia Gibbs, Robert M. Blizzard, Diabetes mellitus: the incidence of circulating antibodies against thyroid, gastric, and adrenal tissue. The Journal of Pediatrics. ,vol. 77, pp. 304- 306 ,(1970) , 10.1016/S0022-3476(70)80342-0
A.C. MacCuish, W.J. Irvine, Autoimmunological aspects of diabetes mellitus Clinics in Endocrinology and Metabolism. ,vol. 4, pp. 435- 471 ,(1975) , 10.1016/S0300-595X(75)80028-4