Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial

摘要: BACKGROUND Obese adolescents are at a greater risk of vitamin D deficiency because is thought to be sequestered by excess adipose tissue. Poor status has been associated with higher prevalence the metabolic syndrome, type 2 diabetes, or both in adults and adolescents. OBJECTIVE The objective was determine obese efficacy safety 4000 IU D3/d whether subsequent increased circulating concentrations 25-hydroxyvitamin [25(OH)D] improved markers insulin sensitivity resistance reduced inflammation. DESIGN adolescent patients [n = 35; mean ± SD age: 14.1 2.8 y; BMI (in kg/m(2)): 39.8 6.1; 25(OH)D: 19.6 7.1 ng/mL] were recruited from University Missouri Adolescent Diabetes Obesity Clinic randomly assigned receive either D3 (4000 IU/d) placebo as part their standard care. Anthropometric measurements, inflammatory (IL-6, TNF-α, C-reactive protein), adipokines (leptin, adiponectin), fasting glucose, insulin, HOMA-IR values measured baseline follow-up visits (3 6 mo). RESULTS After mo, there no significant differences BMI, serum markers, plasma glucose between groups. Participants supplemented had increases 25(OH)D (19.5 compared ng/mL for placebo; P < 0.001), (-6.5 +1.2 μU/mL 0.026), (-1.363 +0.27 0.033), leptin-to-adiponectin ratio (-1.41 +0.10 0.045). Inflammatory remained unchanged. CONCLUSION correction poor through dietary supplementation may an effective addition treatment obesity its resistance. This trial registered clinicaltrials.gov NCT00994396.