Clinical Trial of Vitamin D2 vs D3 Supplementation in Critically Ill Pediatric Burn Patients
作者： Michele M. Gottschlich , Theresa Mayes , Jane Khoury , Richard J. Kagan
关键词:
摘要: Background: Hypovitaminosis D exists postburn. However, evidence-based guidelines for vitamin repletion are unknown. This investigation examined differences between D2 and D3 supplementation on outcome in children with burn injuries. Methods: Fifty patients total body surface area of 55.7% ± 2.6% full-thickness injury 40.8% 3.8% were enrolled, ranging age from 0.7–18.4 years. All participants received multivitamin per standardized clinical protocol. In addition, 100 IU/kg D2, D3, or placebo was administered daily during hospitalization using a randomized, double-blinded study design. Assay 25-hydroxyvitamin (D25), 1,25-dihydroxyvitamin (D1,25), (25-OH-D2), (25-OH-D3), parathyroid hormone (PTH) performed at 4 preplanned time intervals (baseline, midpoint, discharge, 1 year postburn). Differences status compared over each specific interval. Results: There no sig...
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sci-hub.se 参考文章(59)
Raphael C. Lee, Amy Brodsky, Anna Chien, Gerald L. Cooke, Incidence of hypertrophic scars among African Americans linked to vitamin D-3 metabolism? Journal of The National Medical Association. ,vol. 97, pp. 1004- 1009 ,(2005)
T Tankova, G Kirilov, R Kovacheva, L Dakovska, A M Borissova, The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. International Journal of Clinical Practice. ,vol. 57, pp. 258- 261 ,(2003)
I Schuster, H Egger, D Bikle, G Herzig, G.S Reddy, A Stuetz, P Stuetz, G Vorisek, Selective inhibition of vitamin D hydroxylases in human keratinocytes. Steroids. ,vol. 66, pp. 409- 422 ,(2001) , 10.1016/S0039-128X(00)00159-8
Ken C Chiu, Audrey Chu, Vay Liang W Go, Mohammed F Saad, None, Hypovitaminosis D is associated with insulin resistance and β cell dysfunction The American Journal of Clinical Nutrition. ,vol. 79, pp. 820- 825 ,(2004) , 10.1093/AJCN/79.5.820
G.Y. Zhang, T. Cheng, Q. Luan, T. Liao, C.L. Nie, X. Zheng, X.G. Xie, W.Y. Gao, Vitamin D: a novel therapeutic approach for keloid, an in vitro analysis. British Journal of Dermatology. ,vol. 164, pp. 729- 737 ,(2011) , 10.1111/J.1365-2133.2010.10130.X
Allan G Need, Michael Horowitz, Howard A Morris, BE Christopher Nordin, Vitamin D status: effects on parathyroid hormone and 1,25-dihydroxyvitamin D in postmenopausal women The American Journal of Clinical Nutrition. ,vol. 71, pp. 1577- 1581 ,(2000) , 10.1093/AJCN/71.6.1577
Catherine M Willis, Emma M Laing, Daniel B Hall, Dorothy B Hausman, Richard D Lewis, A prospective analysis of plasma 25-hydroxyvitamin D concentrations in white and black prepubertal females in the southeastern United States The American Journal of Clinical Nutrition. ,vol. 85, pp. 124- 130 ,(2007) , 10.1093/AJCN/85.1.124
Lorenzo Piemonti, Paolo Monti, Marina Sironi, Paolo Fraticelli, Biagio Eugenio Leone, Elena Dal Cin, Paola Allavena, Valerio Di Carlo, Vitamin D3 Affects Differentiation, Maturation, and Function of Human Monocyte-Derived Dendritic Cells Journal of Immunology. ,vol. 164, pp. 4443- 4451 ,(2000) , 10.4049/JIMMUNOL.164.9.4443
Cheryl D. Toner, Cindy D. Davis, John A. Milner, The vitamin D and cancer conundrum: aiming at a moving target Journal of The American Dietetic Association. ,vol. 110, pp. 1492- 1500 ,(2010) , 10.1016/J.JADA.2010.07.007
Curtis J. Wray, Theresa Mayes, Jane Khoury, Glenn D. Warden, Michele Gottschlich, The 2002 Moyer Award. Metabolic effects of vitamin D on serum calcium, magnesium, and phosphorus in pediatric burn patients. Journal of Burn Care & Rehabilitation. ,vol. 23, pp. 416- 423 ,(2002) , 10.1097/00004630-200211000-00007