Why do we know so much about wound healing- and yet so little about Keloids?

作者: Ernst Reichenberger

DOI: 10.4172/2325-9620.1000E101

关键词:

摘要: Why do we know so much about wound healing– and yet little Keloids? Wound healing after an injury or a bruise is something our skin deals with everyday by closure subsequent scar formation. After some time may even disappear flatten out. What appears to be simple reaction of the body dermal assault complex series orchestrated events that involves changes in extracellular matrix environment skin, cell migration immune response. The quality depends on many factors such as health status, age, environmental (e.g., medications, nutrition life style) differences gene regulation control succession events. There are number inherited connective tissue disorders affect Marfan syndrome, Ehlers-Danlos epidermolysis bullosa  acute chronic diseases diabetes. Patients reduced response inflammatory can also have delayed healing.

参考文章(52)
Williams Cc, De Groote S, Clinical inquiry: What treatment is best for hypertrophic scars and keloids? Journal of Family Practice. ,vol. 60, pp. 757- 758 ,(2011)
Peter B Olaitan, I-Ping Chen, James EC Norris, Richard Feinn, Odunayo M. Oluwatosin, Ernst J Reichenberger, None, Inhibitory Activities of Omega-3 Fatty Acids and Traditional African Remedies on Keloid Fibroblasts Wounds-a Compendium of Clinical Research and Practice. ,vol. 23, pp. 97- 106 ,(2011)
Irene Lara-Corrales, Alan Arbuckle, Sanaz Zarinehbaf, Elena Pope, Principles of Wound Care in Patients with Epidermolysis Bullosa Pediatric Dermatology. ,vol. 27, pp. 229- 237 ,(2010) , 10.1111/J.1525-1470.2010.01086.X
Mehdi Nassiri, Heather Woolery-Lloyd, Sharon Ramos, Sharon E. Jacob, Dijana Gugic, Anita Viciana, Paolo Romanelli, George Elgart, Brian Berman, Vladimir Vincek, Gene expression profiling reveals alteration of caspase 6 and 14 transcripts in normal skin of keloid-prone patients. Archives of Dermatological Research. ,vol. 301, pp. 183- 188 ,(2009) , 10.1007/S00403-008-0880-Z
James D. Russell, Shirley B. Russell, Kathryn M. Trupin, Fibroblast heterogeneity in glucocorticoid regulation of collagen metabolism: genetic or epigenetic? In Vitro Cellular & Developmental Biology – Plant. ,vol. 18, pp. 557- 564 ,(1982) , 10.1007/BF02810079
Barbara Shih, Elloise Garside, Duncan Angus McGrouther, Ardeshir Bayat, Molecular dissection of abnormal wound healing processes resulting in keloid disease. Wound Repair and Regeneration. ,vol. 18, pp. 139- 153 ,(2010) , 10.1111/J.1524-475X.2009.00553.X
Earl F. Bloch, Macy G. Hall, Marilynn J. Denson, Versie Slay-Solomon, Earl F. Block, General immune reactivity in keloid patients. Plastic and Reconstructive Surgery. ,vol. 73, pp. 448- 451 ,(1984) , 10.1097/00006534-198403000-00020
Qunzhou Zhang, Yidi Wu, Cindy H. Chau, David K. Ann, Charles N. Bertolami, Anh D. Le, Crosstalk of hypoxia-mediated signaling pathways in upregulating plasminogen activator inhibitor-1 expression in keloid fibroblasts. Journal of Cellular Physiology. ,vol. 199, pp. 89- 97 ,(2004) , 10.1002/JCP.10452