Impact of serum uric acid on renal function and cardiovascular events in hypertensive patients treated with losartan

摘要: High serum uric acid level (SUA) and chronic kidney disease (CKD) are risk factors for cardiovascular events (CVEs). However, their interactions as remain unknown. This subanalysis of the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study included 7629 patients, in whom creatinine was measured at least twice. The examined impact hyperuricemia (SUA ⩾7 mg dl−1) on CVE according to renal dysfunction whether early changes SUA predicted future glomerular filtration rates (GFRs). mean follow-up period 3.1 years. patients were divided into three groups baseline estimated GFR (eGFR): A, B C eGFR <45, 45–59 ⩾60 ml min−1 per 1.73 m2, respectively. increased from 38.1 57.6, 52.8 67.5 74.7 80.7 ml min−1 1.73 m2 C, In non-hyperuricemic rate 10.83, 4.98 4.21/1000 person-years respectively, while hyperuricemic corresponding values 14.18, 17.02 5.93. Thus, only group (relative (RR) 3.43 (95% confidence interval (CI) 1.55 7.60); P<0.002). final change negatively correlated year 1 (P<0.001). CVEs more frequent those a decrease eGFR. Hyperuricemia may be major determinant CKD stage 3A, involved progression CKD. Changes influence CVE.