Free radicals as reactive intermediates in tissue injury.

摘要: My interest in free radicals as reactive intermediates, which are capable of initiating tissue injury, developed from studies with CCl4 1963. Whilst attempting to understand the mechanism action various substances that protect against certain aspects liver injury produced by I was impressed fact several these ‘protective agents’ were radical scavengers. One such agent’ and scavenger is phenothiazine derivative Promethazine (or Phenergan) had been reportedl 1961 decrease necrosis resulting administration rats. That observation Rees Spector stimulus for me start a long-term investigation on protective substances; we have now accumulated data effectiveness not) more than 60 scavengers relation disturbances caused vivo vitro. In this article, however, will concentrate mainly specific experiments involving make some general points about hepatotoxicity CCl4.