Heterogeneity of genomic breakpoints in MSN-ALK translocations in anaplastic large cell lymphoma
作者： Frederic Tort , Elias Campo , Brad Pohlman , Eric Hsi
DOI: 10.1016/J.HUMPATH.2004.05.006
关键词:
摘要: Anaplastic large cell lymphomas (ALCL) are associated with the t(2;5)(p23;q35) translocation involving anaplastic lymphoma kinase (ALK) and nucleophosmin (NPM) genes. However, genes other than NPM may fuse to ALK in these tumors. In this study we have identified an ALCL a distinctive membrane-restrictive immunostaining which molecular characterization showed new fusion gene between moesin (MSN) different breakpoints previously recognized. The breakpoint occurred exonic sequence, chimeric included intronic sequence of MSN. Identification genomic derivative chromosome 2 revealed 72-base pair deletion both MSN sequences. These findings provide further evidence heterogeneity translocations highlight importance diagnosis identification underlying genetic abnormalities lymphoma.
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