Frequency and antimicrobial susceptibility of bacteria causing bloodstream infections in pediatric patients from United States (US) medical centers (2014-2018): therapeutic options for multidrug-resistant bacteria.
作者： Helio S. Sader , Mariana Castanheira , Jennifer M. Streit , Cecilia G. Carvalhaes , Rodrigo E. Mendes
DOI: 10.1016/J.DIAGMICROBIO.2020.115108
关键词:
摘要: Abstract Studies evaluating large series of pediatric patients with bloodstream infections (BSIs) are scarce. We evaluated the frequency and antimicrobial susceptibility organisms isolated from BSI therapeutic options for caused by multidrug-resistant (MDR) organisms. A total 2423 were consecutively collected 33 US medical centers between 2014 2018, was tested reference broth microdilution methods. Isolates an extended-spectrum β-lactamase phenotype screened genes. Overall, 40.2% Gram-negative bacteria, 57.0% Gram-positives, 2.8% Candida spp. The 5 most common Staphylococcus aureus (26.0%), Escherichia coli (13.0%), coagulase-negative staphylococci (8.3%), Enterococcus faecalis (7.1%), Klebsiella pneumoniae (6.9%). Among S. aureus, 26.0% oxacillin-resistant 99.8% susceptible to ceftaroline (MIC50/90, 0.25/0.5 mg/L). Enterobacterales Pseudomonas aeruginosa isolates combined represented >85% all (100.0%) ceftazidime-avibactam.
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