Local tissue reaction after injection of contrast media on gastric wall of mouse: experimental study for application of contrast media to computed tomography lymphography

摘要: Purpose: Computed tomography (CT) lymphography is a simple technique of sentinel node navigation but tissue reaction after injection contrast media has not been reported yet. Methods: Ninety mice used in this study were divided into three groups: lipiodol, iopamidol, and normal saline. The test compounds given by submucosal to the gastric wall anesthetized mice. specimens subjected histopathological examination. Results: mean grades acute inflammatory response iopamidol lipiodol significantly higher than control group. However, there was no significant difference between injection. grade chronic fibrosis showed differences groups. presence or absence fibrinoid necrosis mesothelial hyperplasia statistical at each time point foam cell, which similar human signet ring cell carcinoma, identified saline group, detected postoperative day 7 Conclusion: We conclude that when as CT an available material for preoperative surgery cancer with acceptable incidence pathological alterations mouse model. Our results are potentially useful clinical (human) application.