The role of sentinel lymph node biopsy in breast cancer.

摘要: Abstract Background: Lymphatic mapping and sentinel lymph node (SLN) biopsy are new techniques that accurately provide crucial staging information while inflicting far less morbidity than complete axillary dissection. As these continue to gain acceptance, issues such as adequacy of training, certification, outcomes measures become increasingly important. The purpose this paper is report the initial lymphatic experience at H Lee Moffitt Cancer Center Research Institute a detailed description technical aspects mapping. Study Design: From April 1994 1998, 700 patients with newly diagnosed breast cancers underwent an IRB-approved prospective trial using combination Lymphazurin (USSC, Norwalk, CT) blue dye filtered technetium 99m-labeled sulfur-colloid. Failure procedure was defined inability detect SLN by either radiocolloid uptake within gamma probe or visualize staining node. Learning curves were then generated failure rate versus serial number for each 5 surgeons involved in study. Results: identified 665 (95.0%). A total 1,348 SLNs successfully removed, which 238 (17.7%) positive metastatic disease 176 (26.5%). In who dissection after biopsy, 173 186 (93.0%). Of patients, 53 (30.6%) had 120 (69.4%) negative SLNs. SLNs, one patient found have on dissection, false-negative 0.83% (95% CI: 0.02%, 4.6%). learning curve representing mean surgeons' indicates average 23 required individual surgeon achieve 90% ± 4.5% success 95% 2.3% (p = 0.05). Conclusions: These data validate indispensable tools surgical treatment cancer. With adequate multidisciplinary can be readily implemented institutions treating