Antimicrobial activity of Ulopterol isolated from Toddalia asiatica (L.) Lam.: A traditional medicinal plant

摘要: Abstract Ethnopharmacological relevance The leaves of Toddalia asiatica (L.) Lam. (Rutaceae) are widely used in folk medicine India to treat various ailments like cough, malaria, indigestion, influenza lung diseases and rheumatism, fever, stomach ailments, cholera diarrhea. In our earlier communication we have reported the antimicrobial study on extracts isolation identification Flindersine, a quinolone alkaloid as major active principle. present study, report antibacterial antifungal activities Ulopterol, coumarin isolated another Materials methods were successively extracted with hexane, chloroform, ethyl acetate, methanol water. studied for their activity against selected bacteria fungi by using disc-diffusion method. acetate extract which was found possess highest subjected guided fractionation column chromatography over silica gel. This resulted coumarin, Ulopetrol, an principle besides Flindersine us earlier. structure compound elucidated physical spectroscopic data. Ulopterol quantified HPLC. Results showed viz. Staphylococcus epidermidis, Enterobacter aerogenes, Shigella flexneri, Klebsiella pneumoniae (ESBL-3967), Escherichia coli (ESBL-3984) Aspergillus flavus, Candida krusei Botrytis cinerea. Quantification HPLC content be 0.361% 0.266% respectively dry weight basis leaves. Conclusions Ethyl (successive extraction) contained alkaloid, studies. is first also its from plant.