8-Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage
作者： Steffen Loft , Anne Fischer‐Nielsen , Inge B. Jeding , Kirsten Vistisen , Henrik Enghusen Poulsen
DOI: 10.1080/15287399309531806
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摘要: Living organisms are continuously exposed to reactive oxygen species as a consequence of biochemical reactions well external factors. Oxidative DNA damage has been implicated in aging, carcinogenesis and other degenerative diseases. The urinary excretion the repair product 8‐hydroxydeoxyguanosine (8OHdG) proposed noninvasive biomarker oxidative humans vivo. We have developed three‐dimensional HPLC analysis with electrochemical detection for 8OHdG urine studied factors affecting this 83 healthy various laboratory animals, including dog, pig, rat. Previously, groups used comparable methods or gas chromatography‐mass spectrometry selective ion monitoring measuring humans, rats, mice, monkeys. In 169 so far, average was 200–300 pmol/kg per 24 h sevenfold range, coefficient variatio...
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