Minipig models for toxicity testing and biomarkers

Zuhal Dincer, Stewart Jones, Richard Haworth, Preclinical safety assessment of a DNA vaccine using particle-mediated epidermal delivery in domestic pig, minipig and mouse. Experimental and Toxicologic Pathology. ,vol. 57, pp. 351- 357 ,(2006) , 10.1016/J.ETP.2006.03.014

Alexander Wolf, Alexandra Kutz, Sabine Plöttner, Claudia Behm, Herrmann M. Bolt, Wolfram Föllmann, Jürgen Kuhlmann, The effect of benzo(a)pyrene on porcine urinary bladder epithelial cells analyzed for the expression of selected genes and cellular toxicological endpoints Toxicology. ,vol. 207, pp. 255- 269 ,(2005) , 10.1016/J.TOX.2004.09.006

Janos Szebeni, Franco Muggia, Alberto Gabizon, Yechezkel Barenholz, Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention. Advanced Drug Delivery Reviews. ,vol. 63, pp. 1020- 1030 ,(2011) , 10.1016/J.ADDR.2011.06.017

Steffen Loft, Anne Fischer‐Nielsen, Inge B. Jeding, Kirsten Vistisen, Henrik Enghusen Poulsen, 8-Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage Journal of Toxicology and Environmental Health. ,vol. 40, pp. 391- 404 ,(1993) , 10.1080/15287399309531806

Shuji Kitagawa, Kenta Yoshii, Shin-ya Morita, Reiko Teraoka, Efficient topical delivery of chlorogenic acid by an oil-in-water microemulsion to protect skin against UV-induced damage. Chemical & Pharmaceutical Bulletin. ,vol. 59, pp. 793- 796 ,(2011) , 10.1248/CPB.59.793

Michael Alexander, Claudia Behm, Wolfram Föllmann, Jürgen Kuhlmann, Miniaturization of Primary Porcine Urinary Bladder Epithelial Cell Cultures and Application for Gene Expression Studies after Exposure to Benzo[a]Pyrene∗ Journal of Toxicology and Environmental Health. ,vol. 71, pp. 915- 922 ,(2008) , 10.1080/15287390801988830

Mikolaj Milewski, Audra L. Stinchcomb, Vehicle composition influence on the microneedle-enhanced transdermal flux of naltrexone hydrochloride. Pharmaceutical Research. ,vol. 28, pp. 124- 134 ,(2011) , 10.1007/S11095-010-0191-X

Aafje S.A.M. Van der Burght, Mats Tysklind, Patrik L. Andersson, G.Jean Horbach, Martin van den Berg, Structure dependent induction of CYP1A by polychlorinated biphenyls in hepatocytes of male castrated pigs Chemosphere. ,vol. 41, pp. 1697- 1708 ,(2000) , 10.1016/S0045-6535(00)00013-8

János Szebeni, Lajos Baranyi, Sándor Sávay, Michael Bodó, János Milosevits, Carl R. Alving, Rolf Bünger, Complement activation-related cardiac anaphylaxis in pigs: Role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function American Journal of Physiology-heart and Circulatory Physiology. ,vol. 290, ,(2006) , 10.1152/AJPHEART.00622.2005

Yanan Zheng, Devin B. Tesar, Lisa Benincosa, Herbert Birnböck, C. Andrew Boswell, Daniela Bumbaca, Kyra J Cowan, Dimitry M. Danilenko, Ann L. Daugherty, Paul J. Fielder, Hans Peter Grimm, Amita Joshi, Nicole Justies, Gerry Kolaitis, Nicholas Lewin-Koh, Jing Li, Sami McVay, Jennifer O'Mahony, Michael Otteneder, Michael Pantze, Wendy S. Putnam, Zhihua J. Qiu, Jane Ruppel, Thomas Singer, Oliver Stauch, Frank-Peter Theil, Jennifer Visich, Jihong Yang, Yong Ying, Leslie A. Khawli, Wolfgang F. Richter, Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration mAbs. ,vol. 4, pp. 243- 255 ,(2012) , 10.4161/MABS.4.2.19387