Major diencephalic inputs to the hippocampus: supramammillary nucleus and nucleus reuniens. Circuitry and function.

摘要: The hippocampus receives two major external inputs from the diencephalon, that is, supramammillary nucleus (SUM) and reuniens (RE) of midline thalamus. These afferents systems project to separate, nonoverlapping, regions hippocampus. Specifically, SUM distributes dentate gyrus (DG) CA2 dorsal ventral hippocampus, whereas RE projects CA1 subiculum. fibers participate in common as well separate functions. Both would appear amplify signals other sources their respective hippocampal targets. amplifies entorhinal cortex (EC) DG, may them CA3 (and EC) This “amplification” serve promote transfer, encoding, possibly storage information EC DG CA1. Regarding unique actions on is a vital part an ascending brainstem system generating theta rhythm importantly routes medial prefrontal thereby mediate functions involving both structures. In summary, although, date, have not been extensively explored, exert profound influence processes learning memory.