Closed-Loop Interruption of Hippocampal Ripples through Fornix Stimulation in the Non-Human Primate

摘要: Abstract Background Hippocampal sharp-wave ripples (SWRs) arising from synchronous bursting in CA3 pyramidal cells and propagating to CA1 are thought facilitate memory consolidation. Stimulation of the axon collaterals comprising hippocampal commissure rats interrupts leads impairment. In primates, however, these commissural limited. Other fiber pathways, like fornix, may be potential targets for modulating ongoing activity, with short latencies necessary interrupt ripples. Objective The aim this study is determine efficacy closed-loop stimulation adjacent fornix interrupting Method Stimulating electrodes were implanted bilaterally alongside macaque, together microelectrodes targeting hippocampus recording SWRs. We first verified that reliably selectively evoked a response hippocampus. then implemented online detection as occurred. Results interruption method was effective well associated multi-unit demonstrating feasibility ripple using primates. Conclusion Analogous murine research, such an approach will likely useful understanding role SWRs formation macaques other primates sharing humans. More generally, prove interrogating hippocampal-dependent processes. Finally, rapid, contingent-DBS means modifying pathological high-frequency events within hippocampus, potentially throughout extended circuit.