Ultrafiltrate of saliva collected in situ for the measurement of testosterone

摘要: Abstract A device for the in situ collection of an ultrafiltrate saliva was investigated. The collector consists osmotic pump that, when placed mouth, accumulates a prepurified salivary filtrate within few minutes. concentration testosterone and from five male subjects determined by solid-phase immunoassay. can be used without extraction as medium diagnostic evaluation free, protein-unbound testosterone. Concentrations whole correlate closely ( r = 0.89; n 42). potentially measurement wide variety analytes other than An provides following advantages: simplicity collection; moderate stimulation flow; exclusion potential blood contamination; prevention binding to protein; metabolic degradation analytes; reduction viscosity mucopolysaccharides large molecules; sterile sampling ultrafiltrate.