Caractérisation de la génération et la propagation d'ondes de pressions dans des tissus biologiques pour la conception d'appareils médicaux

摘要: Therapies using so called extracorporeal shock waves (Extracorporeal Shock Wave Therapy ESWT) have become current medical practice in orthopedy and traumatology. In order to understand optimize the effect of clinical applications, results must be correlated with well characterized mechanical stimuli. This thesis has an industrial scope. It contributes comprehension generation propagation pressure human tissues aim improving existing ESWT therapies providing partner tools for design a new devices. The adopted general approach is based on combination experimental characterization analytical numerical modeling wave phenomena treatment device biological tissues. Firstly, generator based, one hand, measurements dynamic behavior moving parts coupled rigid body simulation, other hand by means Hopkinson bar finite elements simulations. shown that produces very reproducible stress pulses. simulation technique allows designing higher energy range controlled operating parameters. covered patent. Secondly, measurement soft animal been developed PVDF gages. applicability these gages qualitatively validated comparative bar. perturbation gage, acting as inclusion medium characterized, evaluated simulations water. Comparison suggests it negligible this type materials. An independent calibration gage could however not performed. Finally, pig skin fat gauges showed good reproducibility given sample. They highlighted influence supply amplitude attenuation Moreover, dependence between its velocity non-linear viscoelastic need constitutive model high strain rates. Simulations known hyperelastic difficulty such A power laws was considered interesting candidate future solid (aluminum) liquid (water) comparing performed materials (strain hydrophone respectively). solids liquids they can applied modeled model; are tool any more complex models. work broader study aimed at establishing validating models suitable use propagation.