Antimicrobial and biocompatible fluorescent hydroxyapatite-chitosan nanocomposite films for biomedical applications.
作者： Somtirtha Banerjee , Biswajoy Bagchi , Suman Bhandary , Arpan Kool , Nur Amin Hoque
DOI: 10.1016/J.COLSURFB.2018.07.028
关键词:
摘要: Development of fluorescent erbium doped hydroxyapatite (eHAp)-chitosan nanocomposite film is reported. Nanocrystalline eHAp has been synthesized by hydrothermal assisted precipitation method using (III) ions as dopant. Physico-chemical characterization UV/Visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), photoluminiscence (PL) and Field emission scanning electron microscopy(FESEM) confirmed incorporation uniform distribution in the chitosan films. Strong antimicrobial activity was observed incorporated films against E. coli S. aureus contact inhibition on agar plates. On other hand, excellent biocompatibility with human lung fibroblast cells (WI-38) which showed strong attachment proliferation minimal cytotoxicity. Moreover, good biodegradation mineralization behavior after 2 weeks simulated body fluid. Thus multifunctional attributes can be a candidate for diverse applications like treatments, wound healing, tissue scaffolds bioimaging.
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