Risk Factors Associated with Increased Mortality among HIV Infected Children Initiating Antiretroviral Therapy (ART) in South Africa

摘要: OBJECTIVE: To identify demographic and clinical risk factors associated with mortality after initiation of antiretroviral therapy (ART) in a cohort human immunodeficiency (HIV) infected children KwaZulu-Natal South Africa. METHODS: We performed retrospective study 537 initiating at McCord Hospital Data were extracted from electronic medical records assessed using Cox regression analysis. RESULTS: Overall there 47 deaths the ART over 991 child-years follow-up (median 22 months on ART) yielding rate 4.7 per 100 child years ART. Univariate analysis indicated that was significantly lower weight-for-age Z-score (p<0.0001) chronic diarrhea (p = 0.0002) hemoglobin 0.002) age <3 0.003) CD4% <10% 0.005). The final multivariable proportional hazards model found less than 3 0.004) CD4 0.01) 0.03) (<0.0001) female gender as covariate varying time all mortality. CONCLUSION: In addition to recognized such young advanced immunosuppression we be this pediatric cohort. Future studies are needed determine whether intrinsic biologic differences or socio-cultural place HIV increased death following