The location of the primary colon cancer has no impact on outcomes in patients undergoing cytoreductive surgery for peritoneal metastasis.

摘要: Abstract Background The impact of the location colorectal cancer on patient outcomes has been reported in several settings. objective this study was to assess prognostic primary colon among patients with peritoneal metastases undergoing complete cytoreductive surgery. Methods Using prospectively maintained clinical and biological digestive metastasis database BIG-RENAPE network, we identified 796 treated by a surgery between January 2004 2017 for 16 different institutions. 2 endpoints were overall survival progression-free survival. To evaluate potential factors (including cancer), these included univariate multivariate Cox proportional hazard models. Results Right-sided cancers more often BRAF mutated had microsatellite instability, whereas frequency RAS mutation similar right-sided left-sided cancers. After median follow-up time 3.3 years, there no significant difference or according tumor side. lack effect consistent across subgroups. Conclusion Among metastases, site not associated differences Tumor side should be used as stratification factor trials selection process