Reduced Fetal Telomere Length in Gestational Diabetes

作者: Jian Xu , Junyi Ye , Yanting Wu , Hong Zhang , Qiong Luo

DOI: 10.1371/JOURNAL.PONE.0086161

关键词:

摘要: Gestational diabetes mellitus (GDM) is an important complication of pregnancy that poses significant threats to women and their offspring. Telomere length shortens as cellular damage increases associated with metabolic diseases. in fetal leucocytes was determined 82 infants GDM (N = 82) 65 normal pregnant 65). Women preeclampsia 45) gestational hypertension 23) were also studied. In the group, telomere significantly shorter than (P 0.028), but there no differences between 0.841) 0.561). Regression analysis revealed intrauterine exposure 0.027 after adjustment for maternal age, age at delivery, birth weight gender). Shortened may increase risk diseases adulthood

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