Maternal corticotropin-releasing hormone is increased with impending preterm birth.
作者： C. Korebrits , M. M. Ramirez , L. Watson , E. Brinkman , A. D. Bocking
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摘要: The objective of this study was to test the hypothesis that maternal CRH concentrations are elevated in women experiencing threatened preterm labor who subsequently give birth within 24 h compared those do not. We also characterized changes plasma cortisol, ACTH, corticosteroid binding capacity (CBC), and 28 healthy pregnant between 20-38 weeks gestation. Overall, were significantly greater (P < 0.05) giving (1343.3 +/- 143.9 pg/mL; n = 81) did not (714.5 64.8 144) or normal subjects. This difference present 28-36 weeks, but 24-28 ratio cortisol CBC 0.05; 0.65 0.04; 82) than (0.55 0.02; 136). significant at all gestational ages studied. Elevated bioavailability free may both be implicated pathogenesis some women. Further prospective clinical trials warranted determine positive negative predictive values and/or cortisol/CBC for identifying with destined h.
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