Gestational changes in the levels of transforming growth factor-β1 (TGFβ1) and TGFβ receptor types I and II in the human myometrium

摘要: As term approaches, a number of key proteins [contraction-associated (CAPs)] are expressed within the human myometrium that essential for activation powerful coordinated contractions during labor. The nature signals switch on synthesis CAPs in vivo is not known. ryanodine-sensitive intracellular Ca2+ release channel (RyR2) CAP whose expression vitro activated by transforming growth factor-β (TGFβ). present experiments were performed to determine whether TGFβ and receptors at explore idea they might form part signaling system vivo. receptor types I II, but III, demonstrated myometrial smooth muscle tissue taken from nonpregnant, pregnant nonlaboring, spontaneous laboring women. Western blotting was used subsequently relative II. Using nonpregnant as baseline control levels expr...