Karyotype and age in acute myeloid leukemia. Are they linked

摘要: A novel hierarchical cytogenetic classification for acute myeloid leukemia (AML) has been developed. Patients with successful cytogenetics and a diagnosis of AML were categorized into four mutually exclusive karyotype groups: normal, translocation, deletion trisomy. more than one chromosomal abnormality classified using the hierarchy: established translocation>established deletion>established trisomy>non-established translocation>non-established deletion>non-established total 593 patients from large population-based case-control study according to their diagnostic karyotype. The groups showed different age distributions. Overall frequency increased as did deletion, trisomy or normal Although increase was much sharper deletion. In contrast, distribution translocation roughly constant age. We concluded that there link between patient at diagnosis. Furthermore, two groups, translocations deletions, may define disease entities etiologies. This will allow other studies examine whether cases very types have same etiology.