Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China
作者： Y Cheng , Y Wang , H Wang , Z Chen , J Lou
DOI: 10.1038/LEU.2009.107
关键词: Cytogenetics 、 Population 、 Incidence (epidemiology) 、 Oncology 、 Karyotype 、 Myeloid leukemia 、 Internal medicine 、 Hematology 、 Chromosomal translocation 、 Trisomy 、 Pathology 、 Medicine
摘要: Geographic heterogeneity of cytogenetic patterns in hematological malignancies has been reported earlier, but few systematic studies abnormalities acute myeloid leukemia (AML) patients are available. We examined the karyotypic 1432 de novo AML from a single center China and compared our data with reports other regions world. Chromosomal were detected 746 (58%) cases. The most frequent abnormality was t(15;17), 14% successful cases, followed by t(8;21) 8%, t(9;22), +21 +8 each 2%. mean age translocation karyotype significantly younger than that normal, deletion or trisomy karyotypes. A higher incidence M3 lower frequency M4 observed Asian population frequencies certain aberrations different those earlier reports. Population-based age-specific incidences calculated western
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