Pharmaceutical composition for preventing or treating cancer, containing enoblock as active ingredient
作者： Darren Williams , Da-Woon Jung , Woong-Hee Kim
DOI:
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摘要: The present invention relates to ENOblock, which is a non-substrate analogue having an enolase inhibitory activity, and pharmaceutical composition for preventing or treating cancer enolase-associated diseases, containing the same. ENOblock of directly binds so as inhibit activity thereof, inhibition more effective in hypoxia than normoxia. In addition, inhibits migration, metastasis invasion cells. Furthermore, induces glucose uptake into cells, down-regulates expression PEPCK, adipogenesis foam cell formation. Therefore, can be very effectively applied prevent treat diseases.
lens.org 参考文章(58)
Zhizhong Li, Jeremy N. Rich, Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance Current Topics in Microbiology and Immunology. ,vol. 345, pp. 21- 30 ,(2010) , 10.1007/82_2010_75
Steven W. Gorsich, Vince Barrows, Jennifer Halbert, William W. Farrar, Purification and properties of gammagamma-enolase from pig brain. Journal of Protein Chemistry. ,vol. 18, pp. 103- 115 ,(1999) , 10.1023/A:1020659802760
Ho-Sang Moon, Young-Tae Chang, Alexander Schier, Puja Parikh, Eric Jacobson, Trisubstituted triazines compounds with antitubulin activity ,(2002)
Dale P. Corkery, Graham Dellaire, Jason N. Berman, Leukaemia xenotransplantation in zebrafish – chemotherapy response assay in vivo British Journal of Haematology. ,vol. 153, pp. 786- 789 ,(2011) , 10.1111/J.1365-2141.2011.08661.X
Alfonso R. Gennaro, Joseph P. Remington, Remington's pharmaceutical sciences Published in <b>1975</b> in Easton Pa) by Mack. ,(1985)
Shinobu Mochizuki, Akira Miyake, Kiyoshi Yahiro, Kazuhiro Nakatou, Masanori Miura, Eiichi Nakai, Takeshi Suzuki, Hideki Kubota, 2,4,6-triamino-1,3,5-triazine derivative ,(2003)
Emily Jane Gallagher, Derek LeRoith, Diabetes, cancer, and metformin: connections of metabolism and cell proliferation Annals of the New York Academy of Sciences. ,vol. 1243, pp. 54- 68 ,(2011) , 10.1111/J.1749-6632.2011.06285.X
Panagiotis Prinos, Elias Georges, Anne-Marie Bonneau, RNAi-mediated knockdown of α-enolase increases the sensitivity of tumor cells to antitubulin chemotherapeutics. International journal of biochemistry and molecular biology. ,vol. 2, pp. 303- 308 ,(2011)
Anton Franz Josef Fliri, Eric Robert Larson, Jotham Wadsworth Coe, Takushi Kaneko, Triazine derivatives for enhancing antitumor activity ,(1992)
Young-Tae Chang, Darren R. Williams, Da-Woon Jung, Method for screening diabetes treating agent ,(2011)