Folate deficiency in the livers of diethylnitrosaminetreated rats.

摘要: The effects of diethylnitrosamine on the metabolism folic acid and related compounds in rat liver were investigated. administration, drinking water, diethynitrosamine to rats for 3 weeks led decreased hepatic levels folate, S-adenosylmethionine, 5-methyltetrahydrofolate:homocysteine methyltransferase. Liver methylenetetrahydrofolate reductase unaffected by administration diethylnitrosamine. polyglutamate fraction folates obtained from treated with prior injection [3H]folate contained less radioactivity than did livers control alone. Similarly, folate that simultaneously perfused both label only. Livers [2-14C]histidine produced more formiminoglutamate CO2 changes noted diethylnitrosamine-treated resemble those seen methyl-deficient rats.