Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study.

摘要: We studied whether moderate alcohol drinkers have a lower total and coronary heart disease (CHD) mortality than nondrinkers. Among 276,802 U.S. men aged 40-59 enrolled in 1959 an American Cancer Society prospective study, 42,756 deaths, 18,771 from CHD, occurred during the following 12 years (3% of cohort was lost to follow-up). Using nondrinkers (55.3% cohort) as reference category, age- smoking-stratified relative risks (RR) were 0.88 for occasional drinkers, 0.84 those drinking 1 drink per day, 0.93, 1.02, 1.08, 1.22, 1.38 2, 3, 4, 5, 6 or more drinks respectively. RRs CHD 0.86, 0.79, 0.80, 0.83, 0.74, 0.85, 0.92, Multivariate analysis failed identify other confounders. No changes introduced by excluding subjects with poor health history chronic at enrollment (32.8% who died first follow-up. These data indicate apparent protective effect intake on that cannot be attributed inclusion related diseases into nondrinker category.