Effects of vinblastine on blood flow of solid tumours in mice
作者： Maja Cemazar , S. Kranjc , T. Jarm , G. Sersa , A. Secerov
DOI: 10.1007/978-3-540-73044-6_120
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摘要: The aim of our study was to determine the effects low doses Vinblastine (VLB) on tumor growth and time course blood flow changes in solid tumors mice. Two murine were used study; EAT carcinoma SA-1 fibrosarcoma, syngeneic CBA A/J mice, respectively. Mice treated with intraperitoneal injection 2 different VLB when reached 6 mm diameter. Antitumor effectiveness determined by delay assay. Tumor perfusion assessed means Laser Doppler flowmetry. antitumor both minimal, resulting 2.0 days delay. also but dose dependent; lower induced 1.1 delay, while higher resulted 2.1 This 50 μg produced statistically significant highly reproducible decrease flow. maximum effect 1.5 hours after treatment. did not significantly affected perfusion. Our data demonstrate that at minimally affect growth, have a
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