Mitomycin C in corneal refractive surgery.

摘要: Mitomycin C has played a deciding role in the current revival of excimer laser surface ablation techniques. We review literature regarding mechanism action mitomycin C, histological effects on cornea, and indications, dose, exposure time, toxicity corneal refractive surgery. is an alkylating agent with cytotoxic antiproliferative that reduces myofibroblast repopulation after and, therefore, risk postoperative haze. It used prophylactically to avoid haze primary therapeutically treat pre-existing There no definite evidence establishes exact diopter limit or depth at which apply prophylactic C. usually applied concentration 0.2mg/ml (0.02%) for 12 120 seconds over ablated stroma, although some studies suggest lower concentrations (0.01%, 0.002%) could also be effective preventing when treating low moderate myopia. This dose not been associated any clinically relevant epithelial toxicity. Its effect endothelium more controversial: two report decrease endothelial cell density, but majority reports altered. Regarding C's keratocyte population, animal depletion its use, longer follow-up suggested initial does persist time.