Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance.

摘要: Cytotoxic activity attributable to natural killer (NK) cells was augmented in the spleens of mice infected with murine cytomegalovirus (MCMV). Stimulation observed as early 10 hr after virus administration but dependent upon dose used, and particular, host genotype. Effector were capable killing a range tumor cell targets well normal syngeneic thymocytes, induced nude (nu/nu) heterozygous (nu/+) mice. A significant correlation existed between resistance lethal effects MCMV infection degree NK augmentation by this 11 strains examined. Non-H-2 related differences observed, clear association high responses possession particular H-2 haplotype not apparent. Beige mutant C57BL/6J mice, previously reported defective function susceptible expressed low levels cytotoxicity during infection. Thus, genetically controlled stimulation stages may contribute genotype patterns seen virus.