Genetic and phylogenetic analysis of multi-continent human influenza A(H1N2) reassortant viruses isolated in 2001 through 2003.
作者： M.-J. Chen , T. La , P. Zhao , J.S. Tam , R. Rappaport
DOI: 10.1016/J.VIRUSRES.2006.07.010
关键词:
摘要: Abstract Genetic analyses were performed on 228 influenza A(H1) viruses derived from clinical subjects participating in an experimental vaccine trial conducted 20 countries four continents between 2001 and 2003. HA1 phylogenetic analysis of these showed multiple clades circulated around the world with regional prevalence patterns. Sixty-five identified as A(H1N2), 40 which isolated South Africa. The sequences cluster published H1N2 phylogenetically share them diagnostic signature V169A A193T changes. results also for first time that prominent Africa during 2001–2002 season, accounting over 90% cases our study, infecting both children (29/31) elderly (11/13). Phylogenetic 65 we identified, conjunction 56 recent currently available database, provided a comprehensive view circulation evolution distinct temporal manner early mid-2003, shortly after appearance reassortant or near year 2000.
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