Integrated Immunomodulatory Mechanisms through which Long-Chain n-3 Polyunsaturated Fatty Acids Attenuate Obese Adipose Tissue Dysfunction

摘要: Obesity is a global health concern with rising prevalence that increases the risk of developing other chronic diseases. A causal link connecting overnutrition, development obesity and obesity-associated co-morbidities visceral adipose tissue (AT) dysfunction, characterized by changes in cellularity various immune cell populations, altered production inflammatory adipokines sustain state low-grade inflammation and, ultimately, dysregulated AT metabolic function. Therefore, dietary intervention strategies aimed to halt progression obese dysfunction through any aforementioned processes represent an important active area research. In this connection, fish oil-derived long-chain n-3 polyunsaturated fatty acids (PUFA) form eicosapentaenoic acid (EPA) docosahexaenoic (DHA) have been demonstrated attenuate multiple mechanisms, ultimately affecting function, adipokine production, signaling pathways, all which will be discussed herein.