Inhibitory effect of 2-deoxy-D-glucose on liver tumor growth in rats

摘要: Since tumor cells are more dependent on glycolysis for energy supply than other cells, we tested whether its inhibition by 2-deoxy-D-glucose (2-DG) affects growth. Male Wistar rats were inoculated in the liver with from a chemically induced colonic adenocarcinoma. From day 5 after inoculation 2-DG (400 mg/kg/24 h) was continuously infused into hepatic artery days; controls received saline same fashion. Seven days end of infusion, animals sacrificed. A second experimental group treated isolated perfusion 30 min oxygenated blood through portal vein and simultaneously. In perfusate, 400 mg/kg added, sacrificed at 10 perfusion. first control underwent without 2-DG, i.v. infusion mg/kg/30 min) over days. nontreated also added. All survived procedures. The concentration glucose increased receiving intraarterially but unchanged groups. growth significantly reduced all groups, no difference between It is therefore concluded that potential interest treatment malignancies. local application avoids risk systemic side effects, this approach should be explored further.