Metabolic management of brain cancer.

摘要: Malignant brain tumors are a significant health problem in children and adults. Conventional therapeutic approaches have been largely unsuccessful providing long-term management. As primarily metabolic disease, malignant cancer can be managed through changes environment. In contrast to normal neurons glia, which readily transition ketone bodies (β-hydroxybutyrate) for energy under reduced glucose, strongly dependent on glycolysis energy. The from glucose as major source is an evolutionary conserved adaptation food deprivation that permits the survival of cells during extreme shifts nutritional Only those with flexible genome mitochondria effectively one state another. Mutations restrict genomic flexibility thus making tumor more vulnerable stress than cells. We propose alternative approach management exploits at expense genetically defective metabolically challenged This supported recent studies mice humans treated calorie restriction ketogenic diet. Issues implementation use protocols presented cancer.