Targeting Energy Metabolism in Brain Cancer with Restricted Diets

摘要: Malignant brain tumors are a significant health problem in children and adults. Conventional therapeutic approaches have been largely unsuccessful providing long-term management. As metabolic disorder involving the dysregulation of glycolysis respiration (Warburg effect), malignant cancer can be managed through changes environment. In contrast to that mostly dependent on for energy, normal neurons, glia readily transition ketone bodies (β-hydroxybutyrate) energy vivo when glucose levels reduced. The from as major source is an evolutionary conserved adaptation food deprivation permits survival cells during extreme shifts nutritional Only those with flexible genome one state another. Mutations restrict genomic flexibility. We propose alternative approach management exploits flexibility at expense genetically defective less metabolically tumor cells. This supported by recent studies orthotopic mouse models human pediatric astrocytoma treated caloric restriction ketogenic diet. Issues implementation use protocols discussed.