Population-based epidemiologic data on brain tumors in German children

摘要: BACKGROUND Brain tumors are the most common disease group of solid in childhood, and children with brain have a relatively poor survival rate. Epidemiologic data from population-based cancer registry provide necessary information to obtain full picture frequency this disease, which is great challenge pediatric oncology. METHODS The German Childhood Cancer Registry (GCCR) registry. The level completeness patient registration 95%, but it somewhat lower for patients tumors. More than 300 newly diagnosed reported every year. Analyses GCCR performed according International Classification recently published World Health Organization classification nervous system. In addition, incidence rates childhood Germany compared those other countries, as by Agency Research on Cancer. RESULTS In years 1990–1999, total 3268 were observed (excluding intracranial intraspinal germ cell tumors). respective rate age < 15 was 2.6 per 100,000 lies between range 1.7 4.1 children. astrocytomas (41.7%), medulloblastomas (18.1%), ependymomas (10.4%), supratentorial primative neuroectodermal (PNETs; 6.7%), craniopharyngiomas (4.4%). They located mainly cerebellum (27.9%) cerebrum (21.2%). 5-year all 64%, poorest prognosis PNET. CONCLUSIONS The large base made possible present representative central system Germany. quality high, not least because strong cooperation corresponding clinical trials. However, tumors, ascertainment needs further improvement. 2001;92:3155–64. © 2001 American Society.