Use of sleep medications and risk of cancer: a matched case-control study.

摘要: Summary Background Previous research suggests a possible link between sleep-medication use and mortality, especially cancer deaths, but findings are mixed, large population-based studies lacking. Methods Data from the Finnish Public Sector study were linked to Cancer Register Drug Prescription of Finland. A total 5053 cases (mean age 57.4 years) diagnosed in 2002–2011, their 24,388 controls free matched for sex, age, socioeconomic status, employer, geographical area, identified. The sleep medications was defined as purchases prescribed medications. Results Both quantity duration prior during seven years studied associated with increased odds having cancer. Compared participants not using medications, ratio 1.18-fold (95% confidence interval (CI): 1.01–1.39) those who used >100 daily doses per year 1.16-fold CI: 1.01–1.34) had such medication >3 years. Site-specific analyses showed more pronounced association subsequent respiratory system (odds vs. no use: 3.47; 95% 1.97–6.11). No associations found other sites. Conclusion In this register-based study, an incidence system. Further needed examine potential carcinogenic mechanisms hypnotic