Intrathecal fentanyl abolishes the exaggerated blood pressure response to cycling in hypertensive men.

摘要: The increase in blood pressure observed during physical activities is exaggerated patients with hypertension, exposing them to a higher cardiovascular risk. Neural signals from the skeletal muscles appear be overactive, resulting this abnormal response hypertensive patients. In present study, we tested whether attenuation of these neural could normalize their activity. Attenuation leg intrathecal fentanyl injection reduced men cycling exercise level comparable that normotensive men. Skeletal muscle afferent overactivity causes and was reverted experimental model, appearing as potential target for treatment. Hypertensive an elevated risk exercise. Although controversial, human studies suggest group III IV afferents might contribute response. investigated signal eliminates occurring Eight performed two sessions 5 min at 40 W. Between sessions, subjects were provided lumbar fentanyl, μ-opioid receptor agonist, aiming attenuate central projection opioid-sensitive nerves. compared six During cycling, demonstrated (mean ± SEM: +17 3 vs. +8 1 mmHg, respectively; P 0.05). Fentanyl inhibited (+11 2 mmHg) (P > Moreover, increased responses vascular conductance stroke volume results study show pressor reflex normalizes individuals.