Effect of Food on Propranolol Oral Clearance and a Possible Mechanism of This Food Effect

摘要: To better define the mechanism of increased plasma concentration propranolol (PL) after meals, effect dietary constitution a meal on kinetics PL and β-naphthoxylactic acid (NLA), main metabolite, administration drug, was investigated in rats. Additionally, hepatic uptake cytochrome P-450 (P-450) content uridin 5'-diphosphoglucuronyltransferase (UDPGT) activity liver were measured glucose intake. As result, protein (skim milk) intake slightly, but not significantly, area under concentration-time curve (AUC) bioavailability PL, with slight increase (16%) blood flow, enhanced metabolism to NLA. Soybean oil fatty significantly decreased while dramatically at high levels, resulting decrease initial time period inhibition metabolic conversion Thus, possible involved food could have been due largely microsomal intake, only partly flow