Effect of food components and dosing times on the oral pharmacokinetics of nifedipine in rats
作者： Qing-Ri Cao , Jing-Hao Cui , Jun Bom Park , Hyo-Kyung Han , Jaehwi Lee
DOI: 10.1016/J.IJPHARM.2010.06.002
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摘要: The present study was aimed to investigate the effect of food components and dosing time on the oral exposure of nifedipine in rats. Nifedipine was given orally to rats with and without food components at 8: 00a. m.(morning time) or 4: 00p. m.(evening time) during winter periods. Food components included milk, sodium chloride, oleic acid, and sodium taurocholate. Plasma concentration profiles of nifedipine showed double peak phenomena which were generally retained regardless of food components, vehicle types and the dosing …
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