Allograft vein patency in a canine model. Additive effects of cryopreservation and cyclosporine.

摘要: Autogenous saphenous vein is the preferred conduit for many cardiovascular operations. Attempts to use allograft veins arterial reconstruction have had poor results. To define circumstances under which might prove be acceptable vascular conduits, dogs underwent femoral artery bypass using reversed veins. Veins were transplanted fresh or after cryopreservation. Group I received a autograft replace one (group F) and cryopreserved (CP) C) other. II veins, group III CP neither receiving additional treatment. IV V veins; both groups cyclosporine 15 mg/kg. Animals maintained until grafts occluded six months elapsed. Patency was observed in all F throughout observation period. Six-month patency rates other were: C, 9/10 (P = NS vs. F); II, 0/10 less than 0.01), III, IV, 1/10 V, 7/11 NS). In separate series of observations 10 implanted that CsA 30 days. then discontinued. All these within days discontinuing CsA. Long-term allografts achieved only with combination cryopreservation immunosuppression continued