Polo kinase Cdc5 associates with centromeres to facilitate the removal of centromeric cohesin during mitosis
作者： Prashant K. Mishra , Sultan Ciftci-Yilmaz , David Reynolds , Wei-Chun Au , Lars Boeckmann
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摘要: Sister chromatid cohesion is essential for tension-sensing mechanisms that monitor bipolar attachment of replicated chromatids in metaphase. Cohesion mediated by the association cohesins along length sister arms. In contrast, centromeric cohesin generates intrastrand and centromeres, while highly enriched, are separated >800 nm at metaphase yeast. Removal necessary separation during anaphase, this regulated evolutionarily conserved polo-like kinase (Cdc5 yeast, Plk1 humans). Here we address how high levels chromatin removed. Cdc5 associates with cohesin-associated regions. Maximum enrichment occurs metaphase-to-anaphase transition coincides removal chromosome-associated cohesin. interacts vivo, required chromatin. Cohesin from requires but distal chromosomal arm sites does not. Our results define a novel role regulating faithful chromosome segregation.
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